Creskoff graduated from the University of Pennsylvania before attending New York University where she received her Master of Fine Arts degree. She has guest-starred in a number of notable television series including Law & Order, Law & Order: Special Victims Unit, The West Wing, Mad Men, Desperate Housewives, Hannah Montana and Curb Your Enthusiasm. She has had recurring roles in The Practice, Girlfriends, Jonas and Hung, becoming a series regular on the show's second season. In 2011 she guest starred in the second season FX series Justified episodes "Save My Love", "The Spoil" and "Brother's Keeper".
Creskoff also co-starred in the sitcoms Greetings from Tucson and Quintuplets, both of which ended after one season.